๐ง Long COVID and Your Brain ๐ง
Dumb and Dumber?
Dumb and Dumber? IQ loss on every COVID-19 infection?
โYour doctor & surgeon โYour pilot โYour heads of state โDriver in the car next to you โYour brain ๐ง ?
Studies have provided substantial evidence that COVID-19 damages the brain, revealing a range of cognitive and neurological damage:
2023
SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges- Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong1,2,15โ , Hongcheng Mai1,2,15โ , Saketh Kapoor1โ , Victor G. Puelles3,4,13,14,
It's always good to remember that 60% of us who had COVID still might have viral protein accumulation in the skull and brain, which can have implications for . The image and video below are from 's work.
Covid-19 will make you stupid
Cognitive dysfunctions in the course of SARSโCoVโ2 virus infection, including NeuroCOVID, frontal syndrome and cytokine storm (Review)
๐พ๐ค๐๐ฃ๐๐ฉ๐๐ซ๐ ๐๐ฎ๐จ๐๐ช๐ฃ๐๐ฉ๐๐ค๐ฃ๐จ ๐๐ฃ ๐ฉ๐๐ ๐๐ค๐ช๐ง๐จ๐ ๐ค๐ ๐๐ผ๐๐โ๐พ๐ค๐โ2 ๐ซ๐๐ง๐ช๐จ ๐๐ฃ๐๐๐๐ฉ๐๐ค๐ฃ, ๐๐ฃ๐๐ก๐ช๐๐๐ฃ๐ ๐๐๐ช๐ง๐ค๐พ๐๐๐๐ฟ, ๐๐ง๐ค๐ฃ๐ฉ๐๐ก ๐จ๐ฎ๐ฃ๐๐ง๐ค๐ข๐ ๐๐ฃ๐ ๐๐ฎ๐ฉ๐ค๐ ๐๐ฃ๐ ๐จ๐ฉ๐ค๐ง๐ข
Since a lot of people don't have access to articles (what happened to free access for manuscripts?). Here goes the most important part:
Neurocognitive defects post acute Covid infections
Long Covid Patients Twice As Likely To Suffer From Depression & Anxiety
NF-ฮบB links COVID-19 to PD | JIR
Role of Inflammation in the Development of COVID-19 to Parkinsonโs Disease
Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols
โThe nervous system, particularly the brain, can become infected by SARS-CoV-2 early in the course of COVID-19 via viral access through the cribriform plate located at the upper part of the nose.. this route is more ominous than previously thought. The pits of the cribriform plate and areas beneath the olfactory bulb including potential spaces such as the air sinuses can be a reservoir for not only viral persistence, but also its replication.. the upper part of the nose and the structures surrounding it appear to be ideal sites for access to the CNS (central nervous system).. This can cause a low-grade inflammation in the meninges and deeper tissues in the neuronal environment triggering neuroinflammation.. [This can cause] Symptoms such as brain fog, cognitive deficits, prolonged anosmia, memory deficits, and deposition of amyloid-like fibrils that cause premature aging in patients with long COVID.."
It's certainly ominous that SARS-CoV-2 can infect my brain instantly and silently.โ
Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity
๐ผ๐ข๐ฎ๐ก๐ค๐๐ ๐๐๐๐ง๐๐๐๐ฉ๐๐จ ๐๐ง๐ค๐ข ๐๐ผ๐๐-๐พ๐ค๐-2 ๐ฅ๐๐ฅ๐ฉ๐๐๐๐จ ๐ง๐๐๐๐๐ก๐ฎ ๐๐ฃ๐ฉ๐๐ง ๐ฃ๐๐ช๐ง๐ค๐ฃ๐๐ก ๐๐๐ก๐ก๐จ, ๐ข๐ฏ๐ฅ ๐ต๐ฉ๐ช๐ด ๐ค๐ข๐ถ๐ด๐ฆ๐ด ๐ข ๐ณ๐ฆ๐ฅ๐ถ๐ค๐ต๐ช๐ฐ๐ฏ ๐ช๐ฏ ๐ต๐ฉ๐ฆ๐ช๐ณ ๐ฎ๐ช๐ต๐ฐ๐ค๐ฉ๐ฐ๐ฏ๐ฅ๐ณ๐ช๐ข๐ญ ๐ณ๐ฆ๐ด๐ฑ๐ช๐ณ๐ข๐ต๐ช๐ฐ๐ฏ.
Covid, study reveals: here's how the virus can increase Parkinson's risks
Covid, study reveals: here's how the virus can increase Parkinson's risks
SARS-CoV-2 infection as a cause of neurodegeneration
๐ง Long COVID and Your Brain ๐ง
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
Even 27 months after recovering from COVID-19, many people still suffer from brain-related issues like cognitive failures and mental fatigue. A recent study used brain scans (fMRI) to investigate why.
Chris Turnbull on Twitter / X
Long COVID: From olfactory dysfunctions to viral Parkinsonism
Long COVID: From olfactory dysfunctions to viral Parkinsonism
โLong COVID: From olfactory dysfunctions to viral Parkinsonismโ
Long COVID: From olfactory dysfunctions to viral Parkinsonism
COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted.
NYC man's fatal brain disease linked to COVID-19: 'Highly likely'
โDoctors from Mount Sinai Queensโ said itโs โhighly likelyโ COVID contributed to a New York City man developing fatal prion disease.โ
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
โwe identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19.โ
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
โIt is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimerโs disease. Little is known about the molecular basis of these manifestations.โ
Google Scholar
importance of neuropsychology in the early rehabilitation of patients with critical illness after acute COVID infection
Google Scholar
Neurological damages in COVIDโ19 patients: Mechanisms and preventive interventions
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced 'brain fog', delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes.. The most frequent imaging features (affecting >60% of patients) include ischemic infarcts, intracerebral hemorrhages, perfusion abnormalities, and leptomeningeal enhancement. Hypometabolism in the pons, cerebellum, bilateral insula, bilateral medial lobes, and prefrontal cortex indicates brain function dysregulation in COVID patients. The high incidence of cerebrovascular events such as ischemic stroke and intracerebral hemorrhage, indicates potential endothelial injury and coagulation dysfunction. Other investigations have also reported hypoxic alterations in the cerebellum and cerebrum, metabolic alterations of astrocytes, microglial activation, neuro-axonal damage, and neuronal loss.."
Alix Burack on Twitter
related:
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Wes Wilson on Twitter
Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid
more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID
this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms
The negative impact of COVID-19 on working memory revealed using a rapid online quiz
โMemory scores for all COVID groups combined were significantly reduced compared to the non-COVID group in every age category 25 years and over...โ
Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic
"Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic"
CAMH study confirms ongoing brain inflammation associated with long COVID
"Whatโs new about this study is that it shows that inflammation is hanging around for a long time in the brains of people with long COVID even after only mild to moderate symptoms of active COVID-19,โ